| Annotated protein: | Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase). Gene symbol: ADCY1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88444 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADCY1 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Wong ST, et al. "Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP" Neuron. 1999 Aug;23(4):787-98 PMID:10482244 |
| Figure(s): | Figure 3, 4 |
| Annotation description: | Wong et.al. studies the role of Calcium-dependent adenylyl cyclases in LTP at the CA3-CA1 synapse in the mouse hippocampus. It is shown that knockout of AC1 or AC8 alone does not affect LTP (Figure 3C). However, in the AC1/8 double knockout, the late phase of LTP could not be evoked. Thus, AC1 and AC8 are required for L-LTP. AC1 and AC8 are thought to induce LTP via the production of cAMP. Downstream targets of AC8 do not seem to be affected by AC1/8 double knockout, since forskolin, a synthetic cAMP analogue, induces potentiation to levels similar to wildtype (figure 4). cAMP will in turn activate PKA, which is also essential for LTP (Abel et.al.). Via a not completely understood mechanism, this ultimately leads to the insertion of additional AMPA receptors (Man et.al.). 24/11/2017 Pim - Since the involvement of PKA was not shown in this paper I did not propose the pathway annation "regulation of PKA signal transduction". |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Abel et.al. shows that PKA, the direct target of cAMP, is required for LTP. @ PMID:9054501 Man et.al. shows that PKA-mediated phosphorylation of GluR1 regulates AMPA receptor trafficking. @ PMID:17360685 |
| SynGO annotation ID: | 471 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |