| Annotated protein: | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1). Gene symbol: GIT1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FF6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GIT1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Montesinos MS, et al. "Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse" Neuron. 2015 Dec 2;88(5):918-925 PMID:26637799 |
| Figure(s): | Figure S1 |
| Annotation description: | Immunohistochemical (IHC) staining on the P18-21 calyx of Held shows GIT1 and VLGUT1 co-localize (Figure S1a) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 1; GIT Localizes to the Edge of AZs and Directly Binds to stonin 2 @ PMID:24882013 |
| SynGO annotation ID: | 4708 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |