| Annotated protein: | Pumilio RNA-binding family member 2. Gene symbol: PUM2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A0G2K8F9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PUM2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Annotated paper: | Vessey JP, et al. "Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function" Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3222-7 PMID:20133610 |
| Figure(s): | Figure 1-3 |
| Annotation description: | Figure 1: Pum2 negatively regulates dendritic outgrowth. Loss of Pum2 leads to enhanced dendritic arborization, and overexpression of Pum2 causes the reverse effect. Figure 2: Pum2 regulates dendritic spine morphology and mEPSC frequency. Figure 3: Pum2 regulates excitatory synapse numbers. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4699 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |