| Annotated protein: | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62). Gene symbol: ELFN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FM6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ELFN2 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Annotated paper: | Dunn HA, et al. "ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior" Mol Psychiatry. 2019 Dec;24(12):1902-1919 PMID:31485013 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | Binding to ELFN2 in trans promotes membrane localization and alters pharmacological properties of group III mGluRs (Figure 2). Knockdown of ELFN2 impairs glutamatergic transmission at CA3-CA1 synapses (Figure 3) |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) FRET IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4690 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |