Annotated protein:Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2). Gene symbol: TNK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: O54967
antibody wiki:
SynGO gene info:SynGO data @ TNK2
Ontology domain:Cellular Component
SynGO term:postsynaptic cytosol (GO:0099524)
Synapse type(s):hippocampus
neocortex
cerebellum
Annotated paper:Urena JM, et al. "Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain" J Comp Neurol. 2005 Sep 19;490(2):119-32 PMID:16052498
Figure(s):Fig 5
Annotation description:Fig 5 shows localisation of TNK2 (ACK1) to both axon terminals and dendritic spines using DAB immunolocalization in mouse hippocampus, neocortex and cerebellum. As the molecule does not contain a transmembrane domain or membrane binding motif, its localisation is cytosolic.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Jan van Weering (ORCID:0000-0001-5259-4945)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:4686
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology