| Annotated protein: | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2). Gene symbol: TNK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: O54967 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TNK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | hippocampus neocortex cerebellum |
| Annotated paper: | Urena JM, et al. "Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain" J Comp Neurol. 2005 Sep 19;490(2):119-32 PMID:16052498 |
| Figure(s): | Fig 5 |
| Annotation description: | Fig 5 shows localisation of TNK2 (ACK1) to both axon terminals and dendritic spines using DAB immunolocalization in mouse hippocampus, neocortex and cerebellum. As the molecule does not contain a transmembrane domain or membrane binding motif, its localisation is cytosolic. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4685 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |