| Annotated protein: | Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]. Gene symbol: NOTCH1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q01705 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NOTCH1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic process involved in chemical synaptic transmission (GO:0099565) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Alberi L, et al. "Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks" Neuron. 2011 Feb 10;69(3):437-44 PMID:21315255 |
| Figure(s): | Figure 4I |
| Annotation description: | Authors use hippocampal slices to measure electrophysiological properties of Notch1 CA1 cKO neurons. Using field recordings, authors find that LTP and LTD, measured at CA3->CA1 connections, were reduced in slices where Notch1 is selectively removed in CA1 neurons. On the other hand, in these conditions there is no presynaptic defect, as authors find that basal transmission was the same for mutants and controls (Figure 4G), and paired-pulse facilitation (Figure 4H). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Carlos Pascual-Caro (ORCID:0000-0002-2345-393X) Anjali Amrapali Vishwanath (ORCID:0000-0002-9888-0928) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) |
| Lab: | ICM - Brain and Spine Institute, Hpital Piti Salptrire, 47 Boulevard de l'Hpital, 75013 Paris, France |
| SynGO annotation ID: | 4683 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |