| Annotated protein: | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62). Gene symbol: ELFN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FM6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ELFN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Annotated paper: | Dunn HA, et al. "ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior" Mol Psychiatry. 2019 Dec;24(12):1902-1919 PMID:31485013 |
| Figure(s): | Figure 1 |
| Annotation description: | This paper described ELFN2 as a new transsynaptic interactor of mGluR7. In Figure 1 evidence is provided that ELFN2 is present in synaptosomal preparations with high enrichment in the postsynaptic density fraction. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) Western blot |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) |
| Lab: | Cell Biology, Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 4680 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |