| Annotated protein: | Huntingtin-associated protein 1 (HAP-1). Gene symbol: HAP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P54256 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HAP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | brain |
| Annotated paper: | Gutekunst CA, et al. "The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human" J Neurosci. 1998 Oct 1;18(19):7674-86 PMID:9742138 |
| Figure(s): | Fig 8a,b |
| Annotation description: | Authors used pre-embedding immunogold EM to study the cellular and subcellular localization of HAP1 in rat brain. They used a polyclonal antibody generated against the amino acids 287-452 from rat HAP1. Electron micrographs show immunogold particles distributed among, and often on the cytoplasmic surface of synaptic vesicles in axon terminals as well as in postsynaptic dendritic spines. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 468 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |