| Annotated protein: | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1). Gene symbol: KIF5C. Taxonomy: Mus musculus (Mouse). Uniprot ID: P28738 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIF5C |
| Ontology domain: | Biological Process |
| SynGO term: | anterograde dendritic transport of messenger ribonucleoprotein complex (GO:0098964) |
| Annotated paper: | Swarnkar S, et al. "Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation" Cell Rep. 2021 Jul 13;36(2):109369 PMID:34260917 |
| Figure(s): | Fig. 1, 2, 4 |
| Annotation description: | Fig. 1: KIF5C shRNA reduced spine density and spontaneous (mini) frequency and amplitude in mouse primary neuronal culture Fig. 2: over expression of full length WT KIF5C increases mini amplitude (not frequency), and dendrite arborisation and spine density Fig 4: WT KIF5C over expression increases translation in synaptosomes (puromycin labeling) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4677 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |