| Annotated protein: | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC). Gene symbol: KIF5B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61768 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIF5B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of synapse structure, modulating synaptic transmission (GO:0098987) |
| Annotated paper: | Zhao J, et al. "Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory" Elife. 2020 Jan 21;9:e53456 PMID:31961321 |
| Figure(s): | Fig. 1, 2, 7 |
| Annotation description: | fig 1: shRNA-mediated depletion of KIF5B (but not KIF5A) reduced the number of mature mushroom shaped spines (while increasing the number of filopodia. Spontaneous (mini) EPSC frequency was reduced while amplitude was unaffected. Fig 2: reduction of spine numbers upon KIF5B depletion can be rescued by KIF5B and by KIF5C, but not KIF5A Fig 7: spine density was reduced in KIF5B conditional null mutant hippocampus with reduced mini frequency and amplitude. |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4676 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |