| Annotated protein: | Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8). Gene symbol: EXOC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62824 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EXOC4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Annotated paper: | Sans N, et al. "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex" Nat Cell Biol. 2003 Jun;5(6):520-30 PMID:12738960 |
| Figure(s): | Fig. 7 |
| Annotation description: | SEC8 binds to SAP102 via its C-term PDZ-binding domain. Overexpression of deletion mutant of SEC8 lacking its 4 amino acid C-term PDZ-binding domain was used as dominant negative approach. Fig. 7 shows that hippocampal neurons transfected with Sec8delta4 have lower intensity of NR2B fluorescence and concomitant lower mEPSC amplitude (mIPSC amplitudes unaffected) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4675 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |