| Annotated protein: | Exocyst complex component 7 (Exocyst complex component Exo70) (rExo70). Gene symbol: EXOC7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O54922 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EXOC7 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Lira M, et al. "The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons" Mol Neurobiol. 2019 Jul;56(7):4620-4638 PMID:30374940 |
| Figure(s): | Fig. 5, 6 |
| Annotation description: | Fig. 5: Endogenous Exo70 is associated to synapse junctions. The brains from 12 weeks-old rats were fractionated by differential centrifugation. Exo70 is present in ELKS2-positive, Synaptohysin-negative PSD fraction. Fig. 6: Endogenous Exo70 is found in both pre- and postsynaptic compartments: Rat hippocampal neurons were fixed at DIV 21 and immuno-stained for Exo70. Co-localization was observed with SHANK2 (post) and Bassoon (pre). No quantification. Exo70 puncta were also present without Shank2 or Bassoon colocalization |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution Confocal Biochemical fractionation (generic) Western blot |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4671 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |