Annotated protein:Exocyst complex component 7 (Exocyst complex component Exo70) (rExo70). Gene symbol: EXOC7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O54922
antibody wiki:
SynGO gene info:SynGO data @ EXOC7
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):hippocampus
Annotated paper:Lira M, et al. "The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons" Mol Neurobiol. 2019 Jul;56(7):4620-4638 PMID:30374940
Figure(s):Fig. 5, 6
Annotation description:Fig. 5: Endogenous Exo70 is associated to synapse junctions. The brains from 12 weeks-old rats were fractionated by differential centrifugation. Exo70 is present in ELKS2-positive, Synaptohysin-negative PSD fraction.

Fig. 6: Endogenous Exo70 is found in both pre- and postsynaptic compartments: Rat hippocampal neurons were fixed at DIV 21 and immuno-stained for Exo70. Co-localization was observed with SHANK2 (post) and Bassoon (pre). No quantification. Exo70 puncta were also present without Shank2 or Bassoon colocalization
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Super resolution
Confocal
Biochemical fractionation (generic)
Western blot
Annotator(s):Ruud Toonen (ORCID:0000-0002-9900-4233)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:4671
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology