| Annotated protein: | ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG). Gene symbol: ELAVL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70372 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ELAVL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Suhl JA, et al. "A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR" Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6553-61 PMID:26554012 |
| Figure(s): | Fig. 4 |
| Annotation description: | Immunofluorescence on primary cortical mouse neurons shows the presence of the HuR (ELAVL1) in dendrites. Fig. 4E supports the IF data by whole-cortical synaptoneurosome preparation. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Table 1S: The protein was detected in MS in mouse (M. musculus; 6-8-week-old 129 Strain) and zebrafish (D. rerio; adult male and females) whole brain synaptosomal preparations. @ PMID:28252024 Table T1: protein reproducibly detected in mouse synaptosome preparation. @ PMID:25211037 |
| SynGO annotation ID: | 466 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |