| Annotated protein: | SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap). Gene symbol: SRCIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QXY2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SRCIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Jaworski J, et al. "Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity" Neuron. 2009 Jan 15;61(1):85-100 PMID:19146815 |
| Figure(s): | Figure 7 |
| Annotation description: | Figure 7. "immunofluorescent staining of p140Cap in cultured neurons revealed granular puncta of different size that were distributed along dendrites and concentrated within F-actin-enriched dendritic spines (Figure 7C). The p140Cap puncta were not restricted to the spine head but often extended toward the dendritic shaft, suggesting that the zone of p140Cap accumulation might include the neck of the spine. More than 70% of the dendritic p140Cap showed overlap with the postsynaptic marker PSD-95 and presynaptic protein Bassoon (Figure 7E)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4657 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |