| Annotated protein: | SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap). Gene symbol: SRCIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QXY2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SRCIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Annotated paper: | Ito H, et al. "Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex" J Neurochem. 2008 Oct;107(1):61-72 PMID:18662323 |
| Figure(s): | Figure 5, 6 |
| Annotation description: | Figure 5. immunofluorescence labeling and confocal microscopy showed p140Cap (SRCIN1) co-localization of synaptophysin (SYP) in primary cultured rat hippocampal. Fig. 6 Immunoperoxidase electron microscopy of p140Cap showed localization to presynapse and postsynapse. "However, it should be noted that p140Cap was enriched at the pre-synapse and post-synapse in approximately 10% and 80% of synapses analyzed, respectively (data not shown). In the remaining, approximately 10% of the synapses, p140Cap was localized at both pre- and post-synaptic sides (data not shown)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4655 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |