| Annotated protein: | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1). Gene symbol: ACTN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z1P2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ACTN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Annotated paper: | Dhavan R, et al. "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner" J Neurosci. 2002 Sep 15;22(18):7879-91 PMID:12223541 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3. immunostaining and confocal microscopy; "CaMKIIα (CAMK2A), α-actinin-1 (ACTN1), and Cdk5 and its activators colocalize in hippocampal neurons" Potential postsynaptic localization, but in absence of high-resolution data we conservatively opt for "synapse" ontology for now. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | identified α-actinin-1 (ACTN1) in PSD subfractions by mass-spectrometry @ PMID:10818142 |
| SynGO annotation ID: | 4653 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |