| Annotated protein: | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C). Gene symbol: GRIN2C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q01098 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2C |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Yamada K, et al. "NMDA receptor subunits GluRepsilon1, GluRepsilon3 and GluRzeta1 are enriched at the mossy fibre-granule cell synapse in the adult mouse cerebellum" Eur J Neurosci. 2001 Jun;13(11):2025-36 PMID:11422443 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5b,e. ImmunoEM shows localization of GluRε3 (Glutamate receptor subunit epsilon-3, GRIN2C) to postsynaptic densities forming synaptic contacts with mossy fibre terminals in the cerebellar granule layer using immunoperoxidase (b) and postembedding immunogold (e) labeling. "integral component of ... membrane" term was selected based on protein's known transmembrane topology |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4650 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |