| Annotated protein: | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1). Gene symbol: ABI1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QZM5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABI1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Proepper C, et al. "Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation" EMBO J. 2007 Mar 7;26(5):1397-409 PMID:17304222 |
| Figure(s): | Fig. 2 |
| Annotation description: | Fig. 2A Immuno EM detects the protein in dendrites and at PSDs. Fig. 2C supports the EM findings by subcellular fractionations or rat adult brain: the protein is strongly enriched in the PSD fraction. Fig. 2B Further confirms Abi-1 presence at synapses in immunofluorescence on hippocampal rats primary culture at DIV21. Abi-1 colocalizes with markers for excitatory synapses (ProSAP2/Shank3). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Wide-field fluorescence Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 465 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |