| Annotated protein: | Glycine receptor subunit alpha-2. Gene symbol: GLRA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TNC8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRA2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | GABAergic |
| Annotated paper: | Haverkamp S, et al. "Diversity of glycine receptors in the mouse retina: localization of the alpha2 subunit" J Comp Neurol. 2004 Sep 27;477(4):399-411 PMID:15329889 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3. "High-power fluorescence micrographs of vertical sections through the inner plexiform layer of mouse retinae that were doubly labeled for GlyR α2 and synaptic markers." "Figure 3D-F shows a section that was doubly labeled for GlyR α2 (Fig. 3D) and gephyrin (Fig. 3E). Superposition (Fig. 3F) shows that many of the GlyR α2 puncta coincide with gephyrin clusters (boxes in Fig. 3D-F). This was also assessed quantitatively in six sections (see Materials and Methods), and a mean coincidence rate of 46.7% ± 4.4% (mean ± SD) was found." "integral component of ... membrane" term was selected based on protein's known transmembrane topology |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4649 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |