| Annotated protein: | Tetraspanin. Gene symbol: TSPAN7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B0BNE7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TSPAN7 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Bassani S, et al. "The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking" Neuron. 2012 Mar 22;73(6):1143-58 PMID:22445342 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6d. "PICK1 and TSPAN7 interaction in neurons. Immunofluorescence labeling of hippocampal neurons (top) shows that endogenous TSPAN7 and PICK1 colocalize to some extent in dendrites and spines. Coimmunoprecipitation experiments on brain extracts using monoclonal PICK1 antibody (bottom) show that TSPAN7 and PICK1 are associated." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4648 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |