| Annotated protein: | Metabotropic glutamate receptor 2 (mGluR2). Gene symbol: GRM2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q14BI2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Annotated paper: | Toneatti R, et al. "Interclass GPCR heteromerization affects localization and trafficking" Sci Signal. 2020 Oct 20;13(654):eaaw3122 PMID:33082287 |
| Figure(s): | Figure 6, S11 |
| Annotation description: | Figure 6c,d: "Immunogold labeling for anti-mGluR2 immunoreactivity in the frontal cortex of 5-HT2AR+/+ and 5-HT2AR-/- mice (n = 4 mice per genotype and 25 to 35 synapses per mouse). Representative photomicrographs showing excitatory synapses in mouse frontal cortex (C). Quantification of relative distribution of gold particles within postsynaptic spines" "Overall, ~90% of labeled synapses showed gold particles associated within the postsynaptic element, although a small population of synapses contained gold particles limited to its presynaptic compartment" Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4647 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |