| Annotated protein: | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9). Gene symbol: BIN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08539 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Schurmann B, et al. "A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling" Mol Psychiatry. 2020 Sep;25(9):2000-2016 PMID:30967682 |
| Figure(s): | Figure 1, S1 |
| Annotation description: | Although many figures in this paper focus on postsynaptic localization of Bin1, there is also immunogold EM evidence for presynaptic localization of Bin1 in mouse cortex as shown in Figures 1h and S1c. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4645 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |