| Annotated protein: | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9). Gene symbol: BIN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08539 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Schurmann B, et al. "A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling" Mol Psychiatry. 2020 Sep;25(9):2000-2016 PMID:30967682 |
| Figure(s): | Figure 1, 4, S1 |
| Annotation description: | Figure 1,S1. Structured illumination microscopy (SIM) and immunogold EM show Bin1 localization to the postsynaptic compartment Figure 4e,f. SIM microscopy shows Bin1 and GluA1 closely co-localize within dendritic spines. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4644 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |