| Annotated protein: | Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin). Gene symbol: ICAM5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q60625 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ICAM5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Matsuno H, et al. "Telencephalin slows spine maturation" J Neurosci. 2006 Feb 8;26(6):1776-86 PMID:16467526 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 2. Confocal imaging of cultured mouse hippocampal neurons at DIV14 that were double-immunostained for TLCN (ICAM5) and MAP-2 (dendritic marker), show localization of TLCN (ICAM5) on dendritic filopodia. Figure 4f,j. Analogously, triple-immunostaining for TLCN (ICAM5), PSD95 (DLG4) and synaptophysin (SYP) at DIV14,21,28 shows partial overlap that suggests postsynaptic localization. Figure 4o,p. "Double immunostaining of Bassoon (magenta) and TLCN (green). At 14 DIV, Bassoon-positive presynaptic clusters are frequently apposed to TLCN-positive filopodia." Figure 4s,t. "Double immunostaining of GABAA receptor (magenta) and TLCN (green). Clusters of GABAA receptor show no correlation with TLCN localization at both 14 DIV (S) and 21 DIV (T)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4643 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |