| Annotated protein: | Vezatin. Gene symbol: VEZT. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3ZK22 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VEZT |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Danglot L, et al. "Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation" J Neurosci. 2012 Jun 27;32(26):9007-22 PMID:22745500 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2A, Vezatin labels all stages of spine differentiation. Insets, Higher magnifications of a filopodium (arrowhead) and a thin spine (left). A stubby (arrow) and a mushroom-like (arrowhead) are shown on the right (top and bottom insets). Figure 2B, Confocal images showing that Vezatin (green) and PSD95 (red) colocalize (yellow) at spine heads. Figure 2C. Vezatin extends beyond the PSD95/PSD margin toward the neck of the spine: snapshot of a confocal spine 3D reconstruction (21 DIV). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4637 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |