| Annotated protein: | Vezatin. Gene symbol: VEZT. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3ZK22 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VEZT |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wang Y, et al. "Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity" Cell Death Dis. 2021 Oct 12;12(10):936 PMID:34642320 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2. Confocal immunofluorescence staining of cultured hippocampal neurons demonstrating that Vezatin was localized in neurons positive for the neuronal marker Tubb3 and colocalized with the excitatory postsynaptic marker PSD-95 but not with the excitatory presynaptic marker synapsin 1. further functional studies show that a knockdown of Vezatin affects GluA1 phosphorylation via PKA (suggestive of postsynaptic localization rather than presynaptic, which supports the observations from Figure 2) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | in-situ hybridization showed Vezatin exhibited widespread gene expression with high levels in the hippocampus and medial habenular nucleus. Vezatin interacts with ARF6 in Y2H assay. In hippocampal neurons, Vezatin was localized at dendrites as well as cell bodies. Knockdown of endogenous Vezatin significantly reduced total dendritic length and arborization of cultured hippocampal neurons, while overexpression of Vezatin increased dendritic length @ PMID:20188128 |
| SynGO annotation ID: | 4635 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |