| Annotated protein: | Roundabout homolog 2. Gene symbol: ROBO2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TPD3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ROBO2 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse maturation (GO:0060074) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Blockus H, et al. "Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function" Cell Rep. 2021 Oct 19;37(3):109828 PMID:34686348 |
| Figure(s): | Figure 2, 3, S6 |
| Annotation description: | Figure 2. Robo2 is required for synapse formation in hippocampal CA1 pyramidal neurons. Figure S6A. Robo2 is required for synaptic development, rather than maintenance. Figure 3. Robo2 induces excitatory synapse formation in a Slit-dependent manner. Robo2 does not induce inhibitory synapse formation as evidenced by the absence of clustering the inhibitory presynaptic marker Vgat1 in immunohistochemistry |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4632 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |