| Annotated protein: | Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7). Gene symbol: GRIK3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P42264 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | Cochlear hair cell ribbon synapse |
| Annotated paper: | Fujikawa T, et al. "Localization of kainate receptors in inner and outer hair cell synapses" Hear Res. 2014 Aug;314:20-32 PMID:24858010 |
| Figure(s): | Figure 6e,f |
| Annotation description: | "Figure 6. GluRs show a developmental change of expression in outer hair cells. The apical turn (a) and basal turn (b) of whole-mount rat cochleae at P8 were used." "Similar to GluK1, GluK3 is expressed in afferent terminals in the apical turn (E), but is diminished in the basal turn (F)." In outer hair cells, GluK3 (GRIK3) is expressed in the basal turn in early development but completely lost in adult (O). Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 1. shows that GRIK3/GluK3/GluR7 is expressed in brain but not cochlear and vestibular ganglion, corroborating the observation in the annotated paper (PMID:24858010) that this protein is not expressed in adult cochlea @ PMID:7891171 |
| SynGO annotation ID: | 4626 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |