| Annotated protein: | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit). Gene symbol: AP2A1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P17426 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP2A1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endocytic zone (GO:0098843) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Fukaya M, et al. "BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3" J Neurosci. 2020 May 27;40(22):4277-4296 PMID:32341099 |
| Figure(s): | Figure 11 |
| Annotation description: | Figure 11 (P,Q) shows α-adaptin localization at the postsynaptic membrane, to the side of the spine and near the PSD, using immunogold labeling in excitatory asymmetric synapses of the mouse hippocampal CA1 region. The α-adaptin antibody is specific to AP2A1 |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Peter McPherson (ORCID:0000-0001-7806-5662) |
| Lab: | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada |
| Additional literature: | Table 1 shows antibody "BD Biosciences Cat# 610501, RRID:AB_397867" is reactive to AP2A1L (αAL) and AP2A1S (αAS) but not AP2A2 (αC) @ PMID:34820873 |
| SynGO annotation ID: | 4607 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |