| Annotated protein: | Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase). Gene symbol: CASK. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62915 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CASK |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Hsueh YP, et al. "Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses" J Cell Biol. 1998 Jul 13;142(1):139-51 PMID:9660869 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4. Subcellular localization of CASK by immunogold EM in rat brain shows both presynaptic and postsynaptic localization (a separate annotation was made for the latter). CASK seems enriched, but not exclusively located, at membranes. Authors remark that CASK is present in synapses but not synapse specific; "However, CASK is not exclusively localized in synapses; it is also present at nonsynaptic plasma membranes and in intracellular compartments. CASK may therefore be present at a variety of membrane domains in neurons, and its compartmentalization between membrane and cytoplasm may be dynamically regulated." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4597 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |