| Annotated protein: | Potassium channel tetramerisation domain containing 12b. Gene symbol: KCTD12B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C7J6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCTD12 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone membrane (GO:0048787) |
| Annotated paper: | Bhandari P, et al. "GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals" Elife. 2021 Apr 29;10:e68274 PMID:33913808 |
| Figure(s): | Figure 3E |
| Annotation description: | - K+-channel tetramerization domain-containing proteins (KCTDs) are auxiliary GABAB receptor (GBR) subunits. - Experiments were performed at the synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN). - pre-embedding immunogold labeling, imaged with TEM. "In MHb terminals in the rostral IPN, Cav2.3 and KCTD12b showed similar localization patterns, with peak particle densities in the active zone and a gradual decrease in density with increased distance from the active zone (Figure 3A,E)." - Figure 2C: immunolabeling of WT and KCTD12b KO mice shows antibody specificity |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4584 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |