| Annotated protein: | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1). Gene symbol: DIP2A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BWT5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DIP2A |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Ma J, et al. "Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin" PLoS Biol. 2019 Oct 10;17(10):e3000461 PMID:31600191 |
| Figure(s): | Figure 1C, 1D |
| Annotation description: | DIP2A is involved in acetylated coenzyme A (Ac-CoA) synthesis and is primarily expressed in the brain regions with abundant pyramidal neurons. Figure 1C: Western blots of isolated synaptosome fractions from murine brain detected the expression of DIP2A in PSD fraction (PSD marker: PSD95) Figure 1D: Immunostaining of cultured neurons with an antibody against DIP2A (produced by the authors) showed localization of DIP2A at dendritic shafts and spines at DIV18 as well as partial colocalization with PSD95. Figure S3B: Western blot demonstrating the specificity of the antibody against DIP2A in the Dip2a KO mice |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) Western blot Biochemical fractionation (generic) |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4577 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |