| Annotated protein: | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2). Gene symbol: SIPA1L2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TE4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIPA1L2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic signaling pathway (GO:0098928) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Andres-Alonso M, et al. "SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals" Nat Commun. 2019 Nov 29;10(1):5448 PMID:31784514 |
| Figure(s): | 8a-g |
| Annotation description: | Authors use a FRET sensor of ERK1/2 activation localized to presynapses and correlate the presence of over-expressed SIPA1L2 with lower fluorescence lifetime of the donor pair, that indirectly indicated ERK activation. In a rescue experiments, restoration of SIPA1L2 rescues the ERK-dependent phosphorylation of Synapsin in sipa1l2-/- cells. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal FRET |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 4571 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |