| Annotated protein: | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) (Serine-rich synapse-associated protein). Gene symbol: SIPA1L2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5JCS6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIPA1L2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Spilker C, et al. "SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2" J Neurochem. 2008 Jan;104(1):187-201 PMID:17961154 |
| Figure(s): | 3d-e, 5c |
| Annotation description: | SPAR2/SIPA1L2 is enriched in the PSD fraction of a PSD preparation from adult rat cerebellum (Figure 3d). It coimmunoprecipitates with ProSAP-interacting protein from the postsynaptic protein complex in rat cerebellar lysate (Figure 3e). Confocal imaging of dendrites from hippocampal neurons shows localization to postsynaptic spines (Figure 5c). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) IP + WB/MSMS Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 4570 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |