| Annotated protein: | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) (Serine-rich synapse-associated protein). Gene symbol: SIPA1L2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5JCS6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIPA1L2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Andres-Alonso M, et al. "SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals" Nat Commun. 2019 Nov 29;10(1):5448 PMID:31784514 |
| Figure(s): | 2a,e-g; 7b,d |
| Annotation description: | Authors used an antibody generated against rat SIPA1L2 to detect the protein in rat hippocampal cultures. Confocal and super-resolution imaging (STED) shows colocalization of the protein with the presynaptic markers Synaptophysin and Bassoon. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 4569 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |