| Annotated protein: | Signal-induced proliferation-associated 1 like 3. Gene symbol: SIPA1L3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LYG2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIPA1L3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization, intracellular component (GO:0099091) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Dolnik A, et al. "Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3" J Neurochem. 2016 Jan;136(1):28-35 PMID:26364583 |
| Figure(s): | Fig. 3, Fig. 4 |
| Annotation description: | With respect to subcellular localization, immunohistochemical, biochemical, and electron microscopy analysis in rat brain clearly delineated that Sipa1l3/SPAR3 protein is present within the postsynaptic compartment (Fig. 3 and p. 34). Sipa1l3/SPAR3 is found in synapses characterized by the presence of PSD95, VGLUT1 (Fig. 3b) and Bassoon (Fig. 4b) and is absent from synapses carrying GABAA receptors and VGAT (Fig. 3b). Sipa1l3/SPAR3 bind to ProSAPiP1/Lzts3 - a component of the postsynaptic Shank scaffolding platform (Fig. 4d,e). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Microscopy (generic) Western blot Biochemical fractionation (generic) Y2H Protein-protein interaction (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4556 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |