| Annotated protein: | Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore potassium channel TPKC1). Gene symbol: KCNK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97438 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNK2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic process involved in chemical synaptic transmission (GO:0099565) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Wang W, et al. "TREK-1 Null Impairs Neuronal Excitability, Synaptic Plasticity, and Cognitive Function" Mol Neurobiol. 2020 Mar;57(3):1332-1346 PMID:31728930 |
| Figure(s): | Figures 1-5 |
| Annotation description: | Figure 1: TREK-1 KO depolarizes membrane potential and increases input resistance of hippocampal pyramidal neurons. Figure 2: TREK-1 KO increases the excitability of CA1 pyramidal neurons. Figure 3: TREK-1 null alters dendritic sprouting and the number of spines Figure 4: TREK-1 KO increases excitatory and inhibitory synaptic transmission in CA1 pyramidal neurons. Figure 5: TREK-1 KO increases Functional Expression of Postsynaptic AMPA Receptors. Dnyanada 11/06/2021: The enhanced functional expression of postsynaptic AMPA receptors is inferred from AMPA-EPSC electrophysiological measurements. This paper does not further investigate this phenotype (eg via immunocytochemistry of surface AMPAR) and hence the general term "postsynaptic process..." was used. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Dnyanada Sahasrabudhe (ORCID:0000-0003-2916-7616) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4554 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |