| Annotated protein: | Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage-gated calcium channel gamma-7 subunit) (Transmembrane AMPAR regulatory protein gamma-7) (TARP gamma-7). Gene symbol: CACNG7. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62956 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNG7 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Studniarczyk D, et al. "TARP gamma-7 selectively enhances synaptic expression of calcium-permeable AMPARs" Nat Neurosci. 2013 Sep;16(9):1266-74 PMID:23872597 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5a: CACNG7 KD granule cells show a decrease in synaptic channel conductance (to 8.9 ± 0.6 pS, n = 9, P = 0.0093) as compared to WT. Figure 4: CACNG7 KD does not affect synaptic localisation of AMPA receptors. Although γ-7 is not essential for synaptic localization of AMPA receptors, the reduction in single-channel conductance suggests that after knockdown of γ-7, the postsynaptic AMPARs may be either TARPless or composed of subunits (such as homomeric GluA2) that give rise to low-conductance channels. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Dnyanada Sahasrabudhe (ORCID:0000-0003-2916-7616) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4553 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |