| Annotated protein: | CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44). Gene symbol: CD44. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P26051 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CD44 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic structure (GO:0099159) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Roszkowska M, et al. "CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines" Mol Biol Cell. 2016 Dec 15;27(25):4055-4066 PMID:27798233 |
| Figure(s): | Figs. 5, 6 |
| Annotation description: | Activity-dependent structural plasticity of dendritic spines is regulated by CD44. Chemical LTP (cLTP) induces massive increase of spine head size. This is suppressed by shRNA-mediated knockdown of CD44 (Fig. 5). The activity-dependent regulation of spine shape may be mediated by differential regulation of small actin cytoskeleton-regulating GTPases RhoA, Rac1, and Cdc42 as shown in a FRET-based assay (Fig. 6). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal FRET |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4550 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |