| Annotated protein: | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362). Gene symbol: SDC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P34900 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SDC2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Hsueh YP, et al. "Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses" J Cell Biol. 1998 Jul 13;142(1):139-51 PMID:9660869 |
| Figure(s): | Figs. 7,8 |
| Annotation description: | Fig. 7 shows the localization of Syndecan-2 at the synaptic membranes both at the pre- and postsynaptic side. Fig. 8 shows an almost symmetric distribution of immunogold particles. Although peaking at the synaptic membrane, syndecan-2 labeling extends deeper into the presynaptic than the postsynaptic side. "integral component .." was inferred from transmembrane topology of Syndecan-2 |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4549 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |