| Annotated protein: | CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44). Gene symbol: CD44. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P26051 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CD44 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Roszkowska M, et al. "CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines" Mol Biol Cell. 2016 Dec 15;27(25):4055-4066 PMID:27798233 |
| Figure(s): | Figs. 2; 4A,B; 6 |
| Annotation description: | Cell adhesion molecule (CAM) CD44 shRNA knockdown reduces spine head width and increases spine length. This phenotype can be rescued by overexpression shRNA-resistent CD44 (Fig. 2). CD44 knockdown also causes a reduction of PSD-95 levels in spines relative to dendrites (Fig. 4A,B). The determination of spine shape seems to be mediated by differential regulation of small GTPases RhoA, Rac1, and Cdc42 by CD44 as shown in a FRET-based assay (Fig. 6). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal FRET |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4548 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |