| Annotated protein: | Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI). Gene symbol: DPP6. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9Z218 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DPP6 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Lin L, et al. "DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development" Nat Commun. 2013;4:2270 PMID:23912628 |
| Figure(s): | Figure S1 |
| Annotation description: | Figure S1A-B: Primary hippocampal neurons stained with anti-DPP6 antibody show localisation in the dendritic spines. Majority of the anti-DPP6 puncta colocalises with postsynaptic density marker PSD95. Figure S1C: The lack of anti-DPP6 staining in DPP6 KO neurons is indicative of the antibody's specificity. The term "synapse" was chosen as the annotated microscopic data doesn't have sufficient resolution for a specific term. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Dnyanada Sahasrabudhe (ORCID:0000-0003-2916-7616) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4538 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |