| Annotated protein: | PRA1 family protein 2. Gene symbol: PRAF2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JIG8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRAF2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | ventral tegmental area, glutamatergic ventral tegmental area, GABAergic |
| Annotated paper: | Cifuentes-Diaz C, et al. "Anatomical and ultrastructural study of PRAF2 expression in the mouse central nervous system" Brain Struct Funct. 2016 Nov;221(8):4169-4185 PMID:26645984 |
| Figure(s): | Fig. 9 |
| Annotation description: | Fig. 9: "PRAF2 is expressed in post and presynaptic terminals of the VTA." "A, B, PRAF2 immunoperoxidase staining is present in axosomatic contacts. PRAF2 is readily detected as a dark amorphous, diaminobenzidine (DAB) reaction product, staining the vesicles ... and mitochondria enclosed in the axon terminal." "Gold particles labeling in axon terminals ... contacting neuronal soma (H) or dendrite (I)." "Both asymmetric (Fig. 9A, B, D, F, G) and symmetric (Fig. 9C, E) synapses were stained, suggesting that PRAF2 is expressed in excitatory and inhibitory synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4519 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |