| Annotated protein: | Neurocan core protein (Chondroitin sulfate proteoglycan 3). Gene symbol: NCAN. Taxonomy: Mus musculus (Mouse). Uniprot ID: P55066 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCAN |
| Ontology domain: | Cellular Component |
| SynGO term: | perisynaptic extracellular matrix (GO:0098966) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Mohan V, et al. "Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons" Front Cell Neurosci. 2018 Oct 9;12:346 PMID:30356641 |
| Figure(s): | Fig. 2 A,D,E |
| Annotation description: | The electron micrograph (Fig. 2A) of MFC layer 2/3 at P18 shows immunogold labeling of Neurocan near the plasma membrane adjacent to a spine (Sp) and axon terminal. Fig 2D shows Neurocan labeling adjacent to axon terminals (AT) at P18. Fig. 2E depicts Neurocan labeling at neck of spine (Sp) and near excitatory synapses at P80. The antibody specificity is confirmed in Fig. 2F. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4516 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |