| Annotated protein: | Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1). Gene symbol: GRID2IP. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q0QWG9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRID2IP |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic cytosolic calcium levels (GO:0099566) |
| Synapse type(s): | cerebellum, glutamatergic Cerebellar granule cell to Purkinje cell synapse |
| Annotated paper: | Takeuchi T, et al. "Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin" PLoS One. 2008 May 28;3(5):e2297 PMID:18509461 |
| Figure(s): | Fig. 4B |
| Annotation description: | Long-term depression (LTD) at parallel fiber-Purkinje cell synapses is enhanced in delphilin KO mice. Ca2+ influx through voltage-gated Ca2+ channels, mGluR1 activation and AMPA receptor activation are required to induce LTD. When the calcium buffer EGTA (10 mM) was introduced into a Purkinje cell, LTD was strongly suppressed in the wild-type mice but only weakly in the mutant mice (Fig. 4B). These results suggest that LTD was induced with less intracellular Ca2+ in the mutant mice. This ticket is related to ticket ID 4511. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4515 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |