| Annotated protein: | cAMP-dependent protein kinase type II-beta regulatory subunit. Gene symbol: PRKAR2B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P31324 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKAR2B |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Fischer QS, et al. "Requirement for the RIIbeta isoform of PKA, but not calcium-stimulated adenylyl cyclase, in visual cortical plasticity" J Neurosci. 2004 Oct 13;24(41):9049-58 PMID:15483123 |
| Figure(s): | Figure 7D |
| Annotation description: | The authors use a PKA RII beta knockout mouse to study its role in synaptic plasticity in the visual cortex. It is shown that long term depression (LTD) is abolished in layer V of the visual cortex. LTD is a postsynaptic process that requires the endocytosis of AMPA receptors (Beattie et al.,Kirkwood and Bear). In the hippocampus, PKA-mediated phosphorylation of GluR1 is required for AMPA trafficking. It has not formally been shown if this is also true in LTD in the visual cortex. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Beattie et.al. demonstrates that LTD requires endocytosis of AMPA receptors. @ PMID:11100150 Man et al. demonstrates that PKA mediated phoshorylation of GluR1 regulates AMPA receptor trafficking. @ PMID:17360685 Kirkwood & Bear demonstrate that LTD at this synapse is blocked by NMDA receptor antagonist AP5. Therefore, LTD is most likely a postsynaptic process at this synapse. @ PMID:8182481 |
| SynGO annotation ID: | 441 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |