| Annotated protein: | cAMP-dependent protein kinase type I-beta regulatory subunit. Gene symbol: PRKAR1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12849 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKAR1B |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Brandon EP, et al. "Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase" Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8851-5 PMID:7568030 |
| Figure(s): | Figure 4 A |
| Annotation description: | A knockout mouse line for PKA R1 beta is used to study its role in synaptic plasticity. It is shown that long term depression (LTD) at the schaffer collaterals is severely reduced in this mouse line. This demonstrates a role for R1 beta in LTD. LTD is a postsynaptic process, requiring the endocytosis of AMPA receptors (Beattie et. al.). The exact mechanisms by which PKAs act in LTD is not understood, but requires phosphorylation of GluR1 (Man et.al.). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Beattie et.al. demonstrates that LTD requires endocytosis of AMPA receptors. @ PMID:11100150 Man et al. demonstrates that PKA mediated phoshorylation of GluR1 regulates AMPA receptor trafficking. @ PMID:17360685 |
| SynGO annotation ID: | 439 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |