| Annotated protein: | cAMP-dependent protein kinase type I-beta regulatory subunit. Gene symbol: PRKAR1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12849 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKAR1B |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Abel T, et al. "Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory" Cell. 1997 Mar 7;88(5):615-26 PMID:9054501 |
| Figure(s): | Figure 4C |
| Annotation description: | The authors use a transgenic mouse line that overexpresses a dominant negative form of PKA RI alpha to study the role of PKA in long-term plasticity (LTP) at the Schaffer collaterals of the hippocampus. It is found that the late phase of LTP (L-LTP) is abolished in this mouse line, strongly suggesting that PKA is required for L-LTP. It is well established that LTP at Schaffer collaterals is a postsynaptic process, requiring the recruitment of AMPA receptors. The exact mechanism of action for PKAs is not understood, but requires the phosphorylation of AMPA receptors (Man et. al). PKA RIB is also involved in LTD (Brandon et.al. 1995), a process that regulates synaptic transmission through endocytosis of receptors. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Man et.al. shows that PKA-mediated phosphorylation of GluR1 regulates AMPA receptor trafficking. @ PMID:17360685 Brandon et.al. 1995 shows that in a RI alpha null mouse, the induction of LTD is severely reduced. @ PMID:7568030 |
| SynGO annotation ID: | 437 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |