| Annotated protein: | cAMP-dependent protein kinase type II-beta regulatory subunit. Gene symbol: PRKAR2B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P31324 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKAR2B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Parisiadou L, et al. "LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity" Nat Neurosci. 2014 Mar;17(3):367-76 PMID:24464040 |
| Figure(s): | Figure 4 F-G |
| Annotation description: | Confocal microscopy experiments described in this article provide evidence that PKA RIIB is present at the postsynapse. Images suggest that RIIB is localized to dendritic spines, but the resolution is not sufficient to make that claim. A knockout control for the antibody is not provided. 23/5/2017: - Fig.4 literal: "Arrows indicate the localization of PKARIIβ at the base of dendritic spines.". I agree on the selected 'postsynapse' term. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Zhong et.al. used overexpression of PKA RIIB with GFP tag in cultured neurons. GFP fluorescence was detected in dendritic spines and shafts, which is in line with Parisiadou et al. @ PMID:19447092 |
| SynGO annotation ID: | 436 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |